MASC Proteomics Subcommittee
The proteomics subcommittee of the Multinational Arabidopsis Steering Committee was established to facilitate the coordination of international research in Arabidopsis thaliana in the area of proteomics.
The throughput and accuracy of protein identification techniques relies strongly on the availability of whole genome sequences. The availability of both a complete genome sequence and high quality genome annotation makes Arabidopsis an ideal system to develop new proteomics technologies. Furthermore, Arabidopsis proteomics research can serve as a paradigm for other plant proteomics research projects and the advancement of plant proteomics in general. Finally, Arabidopsis proteomics enables the development of a unique platform for plant systems biology by integrating proteomics databases with existing transcriptomics and novel metabolomics and bioinformatics initiatives.
Due to the enormous complexity of a dynamic proteome, different approaches have to be combined to measure protein expression and dynamics, stress- and developmental responses, post-translational protein modifications and protein interaction. However, proteomics has not yet reached its goal. We are still in the process of data generation, and in the face of the enormous complexity of the dynamic proteome, substantial method development is still needed, especially in the fields of quantitative proteomics and the dissection of signaling pathways involving post-translational modification.
Therefore, this working group devoted to Arabidopsis proteomics aims to combine the efforts of different research groups to develop programs which will consolidate databases, technique standards and experimentally validated candidate genes and functions.